Special Report From the Desk of David Blyweiss, M.D.
Leading Researchers Reveal Startling Fact:
"Resveratrol is Obsolete!"
Potent resveratrol "cousin" puts resveratrol to shame!
- 400% FASTER and BETTER absorbed than resveratrol!
- Sparks total body energy!
- Absorbs quickly into your cells to naturally fight inflammation, supports healthy blood pressure, blood sugar, and cholesterol!
- Cleanses arteries and supports heart health BETTER than resveratrol
- Turns ON "life extension" genes! Guards cell health and vitality!
- EXTENDS brain cell life BETTER than resveratrol
- Melts body fat 75% BETTER than resveratrol!
Chances are, you already know about resveratrol. You may even be taking it daily.
With good reason!
Resveratrol is known as a miracle for your heart...and a fountain of youth for your whole body.
The discovery of this nutrient, found in the skin of grapes and red wine, was groundbreaking.
For the first time in history we could tap into the miracle of genetic rewriting! By doing nothing more than swallowing a few natural capsules daily...you could change the messages your genes transmit to your body! You could ...
Slash ALL heart health risks and
spark an anti-aging cascade in your cells!
Resveratrol was shown to flush out fat...speed up metabolism...turn on "survival" genes that extend life span in lab animals... support healthy cell turnover... and support healthy cholesterol, blood pressure, and keep blood sugar levels under control. It could even REVERSE the damage of a high fat diet!1
Harvard Medical School, the Mayo Health Clinic, MIT, and other prestigious institutions all reported on it.
60 Minutes, CBS News, CNN, Newsweek, The Wall Street Journal, Fox News all touted this amazing discovery. Barbara Walters of ABC News said that thanks to resveratrol, "living well past 100 could actually be possible."
But alarming new research has revealed the truth about resveratrol.
Did Harvard and 60 Minutes
Get it Wrong About Resveratrol?
You may well remember the first time you heard about resveratrol! It was all over the major media!
Here's what they all said:
"Scientists across the country have identified a substance in red wine called resveratrol that they believe might do more than just protect the heart...If they're right, we may all soon be taking a pill that could give us an extra decade or two of healthy old age."
May 24, 2009 - SOURCE: CBSNEWS.com
"Living well past 100 could actually be possible..."
April 1, 2008 - SOURCE: ABCNEWS.go.com
"Aging as we know it may not be inevitable..."
December 11, 2006 - SOURCE: NEWSWEEK
A leading Harvard scientist reported that mice who were given resveratrol AND fed a high calorie diet not only did not gain weight...they actually had BETTER heart function and blood sugar health.
They had more energy. They lost weight. Resveratrol had rewritten their genes to protect against obesity, disease, and even aging. How did it work?
Resveratrol tricks your body into thinking it's on a very low calorie diet. Extremely low-calorie diets, or "calorie restriction," are nature's fool-proof way to slow your body's rate of aging!
Scientists know that severe calorie restriction switches ON "survival" genes that extend lifespan in lab animals. Those genes also get you amazing changes in cholesterol, blood pressure, and blood sugar levels... and even a 50% slash in the risk of mental decline!"6
And resveratrol could do it all for you! Without a single change in your diet.
Except for one problem:
The dirty little truth about resveratrol…
When researchers took a closer look at resveratrol… they found that something was terribly wrong.
My name is Dr. David Blyweiss.
I'm writing to you today to confirm that...
...you CAN tap into an astounding genetic miracle. You can help protect and rejuvenate your heart.
You can be slimmer and more vital.
And you can naturally support healthy cholesterol, blood pressure, and keep blood sugar under control.
But not by taking resveratrol as you know it.
In research supported by the National Institutes of Health, healthy human volunteers were tested to see how well they absorbed and digested resveratrol.
The study showed that the dose absorbed quickly. But after it was metabolized, researchers found "only trace amounts of unchanged resveratrol" circulating in the body.
In fact, the report stated "Most of the
oral dose was recovered in urine."2
That means your body can't really use it! Now many human studies confirm this: resveratrol supplements yield low blood and tissue levels of resveratrol.3
The reason: it's metabolized too fast.
The liver rapidly breaks it down into a form that no longer has resveratrol's benefits.
What's left is flushed through your body so quickly, it never reaches your entire system.
You're literally flushing your resveratrol supplement down the toilet!
As I said, scientists have uncovered an alarming fact: standard resveratrol supplements pass right through your body!
Your body breaks it down too quickly...and you absorb almost NONE of it!7
However, once the truth about resveratrol came to light, forward-thinking researchers started testing resveratrol analogs, "cousins," found in nature.
And one nutrient came out on top.
It broke through to an even higher level of heart health support. And it delivers more urgent benefits to your cells.
It's called pterostilbene (ter-oh-STILL-bene.) It's found in certain berries, including blueberries, cranberries, and grapes.
Pterostilbene and resveratrol are almost identical. But small differences in pterostilbene's chemical structure make it absorb into cells easier. It's also more stable and slower to be cleared out of the body. 4
Studies comparing resveratrol and pterostilbene show resveratrol's bioavailability is about 20% ... on a good day.
That means your body can use about 20% of it. If that! Pterostilbene weighs in at about 80%...and reaches as high as 94%.5 In other words, pterostilbene kicks resveratrol's butt!
It's 400% better absorbed! Your cells absorb it like a sponge! And that's just the beginning.
- 400% MORE BIOAVAILABLE than resveratrol!
- Absorbs quickly into your cells. Supports healthy cholesterol, blood pressure, blood sugar, and fights inflammation. Supports healthy cells!
- Switches on "life extension" genes!
- Slims your waist 75% BETTER than resveratrol
- Extends brain cell life, improves memory BETTER than resveratrol
This is the real anti-aging breakthrough
you need to know about now!
But there was a problem. Scientists have uncovered an alarming fact: standard resveratrol supplements pass right through your body!
Your body breaks it down too quickly...and you absorb almost NONE of it!6 But the benefits of calorie restriction are real. And researchers have just found a resveratrol "cousin" in nature that absorbs into your system 400% better than resveratrol. Thanks to a small difference in chemical structure, this nutrient molecule is 80-94% absorbed.8
The form of pterostilbene I want to tell you about was reported at the American Heart Association's High Blood Pressure Research 2012 Scientific Sessions to lower blood pressure.
Participants had significant reductions compared to placebo: 7.8 mmHg in systolic and 7.3mmHg in diastolic blood pressure. Pterostilbene also improved weight loss.9
Pterostilbene does EVERYTHING
resveratrol was reported to do.
And much more.
This patented form of pterostilbene...
- Turns on "fat-sensing" complexes that separate harmful from good fats –so your body flushes out the bad. It can lower LDL cholesterol 29%, raise HDL (friendly) cholesterol 7%, and lower blood sugar by 14%.10
- Has 4x the antioxidant power of resveratrol!11
- Could well make you smarter! Researchers at the Department of Neuroscience at Case Western Reserve University reported that "pterostilbene is a more potent modulator of cognition and cellular stress than resveratrol." In a mouse model, pterostilbene, but not resveratrol, controlled cellular stress that can cause mental decline. It even keeps brain cells alive longer!12
- Increases brain proteins linked to better memory.13
- Helps balance blood sugar. Pterostilbene helps lower blood glucose levels.14
- Switches on a cell receptor called PPARalpha. PPARalpha controls inflammation. It even stops artery wall inflammation, which can cause artery hardening. PPARalpha also "talks" to the genes in your body that determine how well your body uses up fat and cholesterol metabolism. PPARalpha also fights inflammation in your liver.15
- Regenerates pancreatic beta-cells, which produce insulin.16
- Stabilizes blood sugar, triglycerides, and insulin resistance even under the stress of a high sugar diet.17
- Supports healthy cell turnover in your arteries. When artery wall cells grow too fast, it can lead to a myriad of heart problems.18
- Improves genetic messengers in your body.19
- And supports healthy cell life span. Pterostilbene is a small molecule that can enter unhealthy cells and block their energy source.20
I'm writing to tell you how you can get pterostilbene today, in a breakthrough new formula called BIO 4.
BIO 4 delivers a patented form of pterostilbene, named "2010 North American Most Promising Ingredient of the Year" by an independent technology research company.
I urge all my patients to take it year round, to keep building on these critical benefits.
And it's just 1 of 4 powerful nutrients in BIO4.
I personally selected the 4 super-nutrients in BIO 4, designed to maximize support for your heart, memory, waistline, and every cell in your body.
And the Pterostilbene in BIO 4 is a proprietary form ensured for safety, purity, and potency.
And it's only the starting point for BIO 4.
I wanted to help get your heart numbers healthy again – and keep them that way.
I wanted this new formula to be an easy, one-dose-a-day solution.
And I wanted it to work so profoundly, that I'd recommend it to all my patients.
I combined nature's 4 most powerful
heart health and longevity nutrients
in one new formula.
The combination of these nutrients is MORE powerful than if you take each one alone.
BIO 4 taps into the synergistic power of these nutrients. Research shows these 4 nutrients work better together, thanks to their special chemical make-up. You won't get the same results by taking each nutrient alone. BIO 4 boosts the total benefits to your body!
And here's another amazing discovery.
We have actually included resveratrol in BIO 4 – but only because we've discovered how to unlock its benefits!
I'll say that again.
We've discovered the secret to unleashing resveratrol's power.
You see, when resveratrol is COMBINED with the right nutrients, all that formerly wasted resveratrol is unlocked and unleashed!
Your body can gobble up ALL its benefits.
Let me give you a specific example.
BIO 4 gives you
"skinny person" genes!
For years, researchers tried to tap into resveratrol's "anti-obesity" effect.
Studies showed resveratrol could rewrite the genes that make "pre-fat" cells turn into full-fledged fat cells. Resveratrol can turn those genes off, so fat cells are killed off before they form!20
But we couldn't unlock its remarkable potential.
Once you add this nutrient to resveratrol, your body will go to work right away, and absorb it like a sponge.
IF you add this nutrient to resveratrol, your body will absorb it like a sponge. You could lose weight like you did when you were 30!
BIO 4 unlocks the fat-fighting benefits of resveratrol!
Researchers tested resveratrol and a related nutrient called quercetin.
Quercetin is a high- potency antioxidant and anti-aging compound found in deep red foods like berries, red apples, and red wine.
Taken together, quercetin and resveratrol are nature's most powerful weight loss secret!
Here's how it works:
Quercetin and resveratrol are both natural fat-fighters.
They both block the process in your body that forms fat cells. It's called adipogenesis.
Quercetin and resveratrol both tell your body to STOP "pre-fat" cells from being fully formed. So your body just flushes them out.
Nature's automatic fat-fighter is in your genes right now.
Turn it on full blast!
Studies show resveratrol alone slashes fat cell creation by 9%.
Quercetin slashes fat cell creation by 15%.
In combination, they reduce fat cell creation by over 68%!
That means quercetin increases resveratrol's fat burning ability by over 75%.
These 2 nutrients also help your body get rid of old or excess fat cells. This natural process, called apoptosis, is also a great natural slimming system! Quercetin PLUS resveratrol increase apoptosis by 18%.22
BIO 4 is a powerful, easily digested single-dose solution for your heart and arteries. The nutrients in BIO 4 are proven to help...
- Fight inflammation
- Support healthy blood pressure
- Support healthy cholesterol levels
- Protect artery wall health
You see, quercetin and resveratrol are both plant compounds known as flavonoids.
Flavonoids bring down inflammation, support a healthy immune system, and work synergistically to guard your heart. That means when you combine them, they're more powerful than the sum of their individual benefits.23
Quercetin and resveratrol combined support healthy blood vessels and halt unhealthy blood vessel formation.24
Quercetin and resveratrol combined relax blood vessels, wash out free radicals, and improve blood flow.25
And BIO 4 just gets more
and more amazing.
You will not find a more potent way to help revive cardio health! Taking pterostilbene PLUS quercetin PLUS resveratrol keeps every cell in your body stronger and well-protected against the ravages of aging and free radicals. When cellular health is guarded, you enjoy maximum nourishment and energy!26
Even on its own, quercetin is a great daily heart protector.
BIO 4 contains 100mg of quercetin. It's exactly what you need every day.
In study after study, quercetin was shown to support healthy cholesterol levels – time and time again. In similar studies, quercetin also produced amazing results in supporting healthy blood pressure and glucose levels.27, 28, 29
Quercetin PLUS resveratrol PLUS pterostilbene is an amazing combination.
But no formula for your heart and energy would be complete without delivering...
The single most important
nutrient for your heart.
If you're over age 40, you must replenish this nutrient.
You may already know about it. It's called CoQ10 (coenzyme Q10.)
Chemist Paul Mitchell was the first to report what CoQ10 does. For his discovery, he was awarded the Nobel Prize in Chemistry in 1978.
CoQ10 unlocks endless energy reserves!
Every cell in your body has an 'energy center' called mitochondria. It's the "power plant" that converts nutrients from the foods you eat into energy. The more energy a cell needs, the more mitochondria it has.
Co-Q10 is the key enzyme inside the mitochondria. It's the spark that sets everything in motion.
But CoQ10 levels fall with age. That leaves you tired, and it may also mean danger for your heart. Your heart muscle cells have a very high number of mitochondria. Your heart needs a constant infusion of CoQ10!
Low CoQ10 levels are even linked to heart failure.30
Plus, the National Library of Medicine and the National Institutes of Health report that heart function may be improved after surgery when CoQ10 is given before or during surgery.31
CoQ10 supplements also improve your exercise capacity!32
And taking CoQ10 is proven to...maintain "optimal cellular health" and "optimal mitochondrial function"... protect the mitochondria against wear and tear ... keep mitochondrial function younger – and less subject to the ravages of age.33
It's no wonder researchers call it, "A Nutrient Critically Important to Normal Heart Function."34
Get BIO 4, with CoQ-10 today!
BIO 4 is the ultimate one-dose solution. Period.
It's 400% BETTER absorbed than resveratrol alone. It burns fat 75% better than resveratrol alone. It protects and IMPROVES brain health better than resveratrol alone. And it sparks a miracle of genetic rewriting – for anti-aging benefits you can see and feel.
Every day you take Bio 4 – just 2 capsules daily is all you need! – you build up more and more protection for your heart. And you support healthier, more vital blood flow.
But don't take my word for it.
BIO 4 works or it's FREE!
I'm confident in your total satisfaction.
That's why I asked the folks who manufacture BIO 4 to extend a special 100% Satisfaction Money-Back Guarantee.
This is a rock-solid guarantee. BIO 4 works, or you don't pay.
Plus, if you order right now, I want you to have a very special gift…
If you're not satisfied, you'll get every penny of your purchase price back.
No questions asked.
Get the Knock-Out Discovery That's
400% More Potent than Resveratrol!
And Get Nature's Ultimate Anti-Aging
and Heart-Smart Nutrients,
in 1 Single-Dose Formula!
It works, or it's yours FREE! Guaranteed.
- Promote healthy blood flow
- Protect artery wall health
- Supports healthy cholesterol levels
- Daily support for blood sugar health
- Amazing breakthrough for healthy pancreas cells
- Take daily for natural anti-inflammatory support
- Support a healthy heart muscle
- Increase exercise capacity
- Increase energy
- Bring back a younger, healthier, more vital you!
- Switch on genes that make every cell in your body act younger and more efficient!
- Guard brain health better than resveratrol
- 75% greater fat-burning power than resveratrol!
- Protect cell walls from the ravages of age!
- Superior anti-oxidant protection!
But I have even better news…
Deep discount for new customers today!
The single bottle price of BIO 4 is $39.95. To slash that down to just $29.99 per bottle, just pick the "Best Deal" option on the Discount Coupon.
Once your shipment of BIO 4 has arrived, take 90 days to make up your mind! If you're not 100% satisfied, return the unused portion of your order – or even the empty bottles – to get every cent of your purchase price back (minus shipping and handling, if any.)
Don't waste another dollar on resveratrol
your body can't absorb!
Send for your risk-FREE supply of BIO 4 – guaranteed for absorption and potency!
BIO 4 is not available in stores.
And you won't find a higher quality one-dose formula anywhere.
BIO 4 is manufactured by a cutting-edge nutraceutical company with a long-standing commitment to superior quality. Every batch of BIO 4 must pass strict Quality Control and chemical analysis testing. Every nutrient in BIO 4 is formulated in a FDA approved cGMP /GLP compliant facility.
BIO 4 is FREE from impurities, pesticides, heavy metals, and harmful agents of any kind. And, in addition to advanced chemical and microbiological analysis, the raw materials in BIO 4 are routinely tested for stability, potency and purity.
Don't throw your money away on nutrient formulas that are not confirmed for active ingredients!
BIO 4 is standardized to ensure active nutrients your body can absorb.
Get the nature's 4 most potent anti-aging cardio nutrients in one daily formula! 100% Risk-FREE!
Yours in excellent health,
David Blyweiss, M.D.
P.S. The 4 nutrients in BIO 4 work together to enhance each other's benefits. These nutrients build up over time, for greater and greater results. So take advantage of the 100% Money-Back Satisfaction Guarantee, and use the full 90 days to decide if BIO 4 is right for you. If you don't enjoy significant improvements to your heart, circulation, metabolism, and energy....if you're not satisfied for ANY reason at all... BIO 4 is FREE!
P.P.S. Select the BEST DEAL option on your Special Discount Coupon (below) and get $59.75 in savings...PLUS a FREE gift worth $29! With the BEST DEAL option, you slash $10 off every bottle of BIO 4. And Shipping and Handling is FREE!
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400% More Powerful Than Resveratrol!
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David Blyweiss, M.D. is compensated by UniScience Group for his work in formulating and endorsing this product.
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2 Drug Metabolism and Disposition, Vol. 32, No. 12
3 Goldberg DM, Yan J, and Soleas GJ (2003) Absorption of three wine-related polyphenols in three different ma- trices by healthy subjects. Clin Biochem 36:79–87; Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 16:1246–1252; 42. Wen X, Walle T (2006) Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos 34:1786–1792
4 Alternative Medicine Review 15 (2): 159–63. 2010. PMID 20807001. http://www.altmedrev.com/publications/15/2/159.pdf
5 Cancer Chemother Pharmacol, November 2010, "Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090701
6 Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period." J Gerontol A Biol Sci Med Sci. 2002 Jun;57(6):B211-24.; "Caloric Intake, Aging, and Mild Cognitive Impairment: A Population-Based Study." American Academy of Neurology Feb 2012.
7 Drug Metabolism and Disposition, Vol. 32, No. 12.
8 Cancer Chemother Pharmacol, November 2010, "Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090701/
10 J Agric Food Chem. 2005 May 4;53(9):3403-7.
11 Plant Foods for Human Nutrition March 2010, Volume 65, Issue 1, pp 57-63
12 Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease.Neurobiol Aging. 2012 Sep;33(9):2062-71.
13 Free Radic Biol Med. 2008 Aug 1;45(3):295-305
14 Mol Cell Biochem. 2002 Dec;241(1-2):53-9.; Life Sci. 2006 Jul 10;79(7):641-5. Epub 2006 Apr 17; Mol Cell Biochem. 2002 Dec;241(1-2):53-9.
15 Biochim Biophys Acta. 2007 Aug;1771(8):972-82. ; J Agric Food Chem. 2005 May 4;53(9):3403-7.
16 Indian Journal of Pharmacology. 1980; 12(2):123-127; J
17 Pterocarpus Marsupium Offsets Stress of a High Fructose Diet Diabetes Obes Metab. Grover JK, Vats V, Yadav SS.
18 Vascul Pharmacol. 2010 Jul-Aug;53(1-2):61-7. doi: 10.1016/j.vph.2010.04.001. Epub 2010 Apr 14.
19 Carcinogenesis. Jul 2009;30(7):1234-42
20 Pterostilben Klls Breast and Prostate Cancer Cells Toxicol In Vitro Chakraborty A, Gupta N, Ghosh K, Roy P.; Pterostilbene Induces Mitochondrial Dysfunction in Breast Cancer Cells J Surg Res. Alosi JA, McDonald DE, Schneider JS, Privette AR, McFadden DW.
21 Mol Nutr Food Res. 2012 Oct;56(10):1559-68. doi: 10.1002/mnfr.201100772. Epub 2012 Sep 4. Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes.
22 Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 2008 May 7;82(19-20):1032-9.
23 Circulation. 2002;105:e53
24 Cancer Lett. 2001 Sep 28;171(1):11-6.
25 Circulation. 2002;105:e53; Am J Clin Nutr November 2000 vol. 72 no. 5 1150-1155
26Antioxidant Effect of trans-Resveratrol, Pterostilbene, Quercetin and Their Combinations in Human Erythrocytes In Vitro Plant Foods for Human Nutrition March 2010, Volume 65, Issue 1, pp 57-63
27 Nutr Res Pract. 2011 Feb;5(1):28-33. doi: 10.4162/nrp.2011.5.1.28. Epub 2011 Feb 28.
28 Med Arh. 2012;66(2):87-8. Quercetin in the treatment of dyslipidemia.
29 Br J Nutr. 2009 Oct;102(7):1065-74. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study.
30 CoQ10 Drug Surveillance Investigators. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med. 1994;15 Suppl:s287-94.
32 Biofactors. 2003;18(1-4):79-89. Overview on coenzyme Q10 as adjunctive therapy in chronic heart failure. Rationale, design and end-points of "Q-symbio"—a multinational trial. Mortensen SA.
33 "Overview of the use of CoQ10 in cardiovascular disease." Biofactors. 1999;9(2-4): 273-84.
34 Biofactors. 2003;18(1-4):101-11.
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